Invokana Has Reported Serious Side Effects

Invokana linked to serious side effects - Legal Examiner




Invokana is linked to serious side effects. Medical experts state Invokana medication is linked to severe and life-threatening side effects including kidney failure, leg amputations, heart attacks and diabetic ketoacidosis., a build up of acid in the body known as diabetic ketoacidosis

Invokana  was the first member of a new generation diabetes drug to hit the market, known as sodium glucose cotransporter 2 (SGLT-2) inhibitors.  Others in this class of drugs include Farxiga, Jardiance, and Invokamet

Increased Risk of Diabetic Ketoacidosis

SGLT-2 inhibitors alter normal kidney functions to increase the amount of sugar excreted in the urine.

As a result of this, the body loses the carbohydrates that it needs to function, and the kidneys become stressed and damaged by sugar molecules.

Because of a reduced amount of circulating sugar, the body goes into “starvation” mode where it begins to break down muscle tissue and stored fat to generate ketones as fuel. This condition is called “diabetic ketoacidosis” and can be deadly if left untreated.

In June 2016, the U.S. Food and Drug Administration (FDA) required the drug makers to add a new Invokana safety warning, highlighting that the diabetic medication may increase the risk of acute kidney injury and kidney failure.

The FDA has also required new Invokana warnings about a risk of diabetic ketoacidosis, a serious medical condition associated with elevated levels of acid in the blood.

Increased Risk of Amputations

Based on new data from two large clinical trials, the FDA in May 2017 concluded that the type 2 diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) causes an increased risk of leg and foot amputations.

Final results from two clinical trials – the CANVAS (Canagliflozin Cardiovascular Assessment Study) and CANVAS-R (A Study of the Effects of Canagliflozin on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus) – showed that leg and foot amputations occurred about twice as often in patients treated with canagliflozin compared to patients treated with placebo, which is an inactive treatment.

As a result one has to question the use of these type of drugs and maybe consider the difficult choice for some to control their diabetes by diet and exercise if it is an option.  At minimum one should question their doctor about diabetes medications prescribed and do your own research,  Your Dr. should closely monitor your health when taking this or other similar medications.  If your Doctor knows less than you do about Diabetes you might want to find another who at minmum is willing to let you take an active role in your own care.

My opinion is that the American Diabetes Association is too chummy with the diabetes drug industry and their  guidelines are not stringent enough to protect your health and your doctor may lack the necessaary education or is just overwhelmed with patients.

 Sitting in a Dr’s Office where my Dad goes you are exposed to one long diabetes commercial interspersed with drug ads .  It tells me that the diabetes epidemic is real and YOU have to be responsible for your own health!  A recent article I posted pointed out the huge number of drugmakers at the ADA conference and the huge money being made by drug companies selling diabetic drugs. Read this post also on this blog,

You can bet that your Dr is getting hit up by attractive drug representatives pushing these various companies drugs with incentives to prescribe them.

Knowledge is Power so visit here often for the latest news!


Diabetes Drugs Cost Soar

The cost for drugs for diabetes has doubled since 2009 in the United States. That is great for drug companies, but also reflects the increasing numbers of people requiring prescription medications to manage their diabetes.

The pharma exhibits at the American Diabetes Association conference here last month stretched across the San Diego Convention Center floor like a mile of drugs.

Displays for Tresiba, Invokana and Victoza, to name just a few, conveyed the largesse of an industry that is skyrocketing by all measures: dollar cost per unit, the number of people purchasing them and the number of prescriptions sold.

With $51.5 billion in U.S. sales in 2016 alone, diabetes drugs had the highest amount of revenue in the nation, above drugs to treat cancer and autoimmune disease, according to QuintilesIMS, which analyzes information from drug companies and suppliers.

Some 29 million people with diabetes across the country take drugs to control glucose. Costs among the 136 brand name drugs soared* from $15.9 billion in sales in 2009 to $32.2 billion in 2014.

Among the 136 top brands analyzed, the drug with the largest revenue increase in 2014 is a pen that delivers doses of insulin by injection, sold as Lantus Solostar. Wholesale sales were up 525 percent from $714.8 million in 2009 to $4.46 billion in 2014.

According to the American Diabetes Association, insulin drug prices overall rose three-fold between 2002 and 2013.

“Insulin prices have skyrocketed,” said Pat VandenHeuvel of San Diego, whose 22-year-old son, William, needs those drugs for his Type 1 diabetes, a genetic form of the disease. For example, their insurance plan now charges $410 as a co-pay for a 20-day supply of one brand of insulin pens, up from about $350 a year ago.

Januvia, another top selling diabetes drug called a DPP-inhibitor, which is taken by oral tablets, increased from $1.53 billion in 2009 to $3.46 billion in 2014, or 126 percent.

Another Lantus insulin pen product was the third largest selling diabetes drug, with $1.9 billion in 2009 sales, growing to $3.4 billion in 2014, a 78 percent increase.

Medicare, which pays for care for some 55 million people, most of them 65 or older, is especially concerned about the cost of treating diabetes and its complications.

Medicare spent $42 billion more in 2016 for services for Medicare beneficiaries with diabetes than for those that did not have diabetes. That included $5 billion for pharmaceuticals to treat diabetes. Per beneficiary, that is $1,500 more on Part D prescription drugs, $3,100 more for hospital and other services, and $2,700 more on physician and other clinical services the agency said.

It is not just the cost of drugs that has been increasing, but also the number of prescriptions. Between 2012 and 2016, the number of prescriptions for diabetes drugs rose from 186 million to 224 million in the U.S., a 20 percent increase. (That 2016 number may actually be higher, because an increasing number of prescriptions are being filled for a 90 day-supply instead of for 30 days.)

According to Quintiles, the “largest drivers” of growth in prescription sales were the increasing number of seniors who are more likely to have health problems requiring drug treatment.

These massive increases are a major reason Medicare officials want to prevent people from getting diabetes in the first place. Starting Jan. 1, it plans to roll out a program, described in an inewsource story June 29, that pays qualifying organizations up to $450 if participants stick to attendance in a year-long lifestyle program with 22 classes and lose 9 percent of their body weight within the year, and $425 if they lose 5 percent.

*The amount does not include reductions in prices due to coupons, discounts, rebates or promotions.